Every stage of the relationship is drawn out: They wait longer to become “official” or exclusive, to move in together, to introduce their partners to their families, to marry and have children. They have less sex than previous generations. They vet partners for financial stability and compatible interests. They cast a wider net than ever before-dating across great geographical divides-and test the waters for long periods over text and videochat before meeting in person. When looking for a soul mate, people no longer rely on blind dates or chance encounters. The way we actually date, though, could hardly be more different. Many today would recognize the appeal of such a picture, however skeptical they might be about the likelihood of this fantasy coming to life. Rapid and deep, true love, for Austen, leaves no room for doubt once it is declared, lifelong commitment-barring intervention by ill fortune or meddlesome relatives-will surely follow quickly on its heels. So begins Jane Austen’s final completed novel, Persuasion-and perhaps no two sentences describe as succinctly the traditional romantic ideal of falling in love. It would be difficult to say which had seen the highest perfection in the other, or which had been the happiest: she, in receiving his declarations and proposals, or he in having them accepted.” “They were gradually acquainted, and when acquainted, rapidly and deeply in love.
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Pathological hallmarks of AD focus primarily on the accumulation of two main protein markers: amyloid β peptides and abnormally phosphorylated tau proteins. Such pathological changes in neurons alone or in combination have been observed in the pathogenesis of various neurodegenerative diseases including Alzheimer’s disease (AD). Aberrant activation of this pathway results in cell death by various mechanisms including apoptosis, necroptosis, pyroptosis, ferroptosis, and autophagy-dependent cell death. Regulated cell death (RCD) is an ordered and tightly orchestrated set of changes/signaling events in both gene expression and protein activity and is responsible for normal development as well as maintenance of tissue homeostasis. 4Department of Surgery, Maharishi Markandeshwar Institute of Medical Sciences and Research, Maharishi Markandeshwar (Deemed to be University), Ambala, India.3Department of Community Medicine and School of Public Health, Post Graduate Institute of Medical Education and Research, Chandigarh, India.2Department of Biochemistry, Maharishi Markandeshwar Institute of Medical Sciences and Research, Maharishi Markandeshwar (Deemed to be University), Ambala, India.1Department of Biochemistry, Shri Atal Bihari Vajpayee Government Medical College Chhainsa, Faridabad, India.Parul Goel 1*, Sasanka Chakrabarti 2, Kapil Goel 3, Karanpreet Bhutani 2, Tanya Chopra 2 and Sharadendu Bali 4 RapidTyping features a simple and intuitive user interface painted with colors to make learning to type fun. 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